Main Cast of Season 1
Season 1 of Grey's Anatomy introduced the original core ensemble at Seattle Grace Hospital. Ellen Pompeo starred as Meredith Grey, the narrator and central character. Patrick Dempsey played Derek Shepherd, Sandra Oh portrayed Cristina Yang, and Katherine Heigl was Izzie Stevens. Justin Chambers, James Pickens Jr., and Chandra Wilson rounded out the primary cast as Alex Karev, Richard Webber, and Miranda Bailey.
Supporting Characters and Storylines
Isaiah Washington played Preston Burke, whose relationship with Cristina Yang became a major early storyline. Kate Walsh appeared as Addison Montgomery, later spinning off into her own series. Sara Ramirez joined as Callie Torres, and Eric Dane played Mark Sloan, both becoming recurring figures by the end of Season 1. The season focused on surgical training, personal trauma, and the doctors' complex relationships.
Where to Watch and Additional Facts
Grey's Anatomy Season 1 premiered on March 27, 2005, and aired 9 episodes. The full first season is available for streaming on Disney+ and other licensed platforms. For detailed episode guides and cast biographies, visit the official ABC Grey's Anatomy page at https://abc.go.com/shows/greys-anatomy.
